| Rank | Twitter Trend | Tweets Count |
|---|---|---|
| 1 | Zendaya | 797908 |
| 2 | #emmys | 775375 |
| 3 | Chelsea | 304740 |
| 4 | #BTSxTinyDesk | 293861 |
| 5 | Thiago | 246139 |
| 6 | Kepa | 236778 |
| 7 | Mane | 163387 |
| 8 | #cheliv | 139966 |
| 9 | Microsoft | 115651 |
| 10 | #WearAMask | 78344 |
| 11 | #EricaXOvation | 64663 |
| 12 | fabinho | 60673 |
| 13 | Christensen | 50072 |
| 14 | #mondaythoughts | 45462 |
| 15 | Kane | 43045 |
| 16 | #ElitesGofundmeFinale | 32409 |
| 17 | Brandon | 27836 |
| 18 | #WeLoveYouOZO | 21280 |
| 19 | #IdolsSA | 14091 |
| 20 | Tyson | 10806 |
| 21 | #TheHeartofMzansi | <10k |
| 22 | #statecaptureinquiry | <10k |
| 23 | ZanoThando | <10k |
| 24 | Guptas | <10k |
| 25 | #Level1Lockdown | <10k |
| 26 | #powertalk | <10k |
| 27 | #VOTEDorathy | <10k |
| 28 | #StayHomeEatOut | <10k |
| 29 | #livebetterAcademy | <10k |
| 30 | #GirlsTalkZA | <10k |
| 31 | ntate thuso | <10k |
| 32 | #jokoyahao | <10k |
| 33 | mr music | <10k |
| 34 | #HeritageDay | <10k |
| 35 | Congratulations Pearl | <10k |
| 36 | #Sidikiwe | <10k |
| 37 | #PrinceKaybeeProducerChallenge | <10k |
| 38 | #monatebreakfastshow | <10k |
| 39 | Pravin | <10k |
| 40 | #Erased | <10k |
| 41 | #OnceAlways | <10k |
| 42 | #JobSeekersSA | <10k |
| 43 | #KingPieHeritage | <10k |
| 44 | #familyfeudsa | <10k |
| 45 | KPMG | <10k |
| 46 | smeg | <10k |
| 47 | Bongani | <10k |
| 48 | #muncry | <10k |
| 49 | #zuluTwitter | <10k |
| 50 | #producerchallenge | <10k |