| Rank | Twitter Trend | Tweets Count |
|---|---|---|
| 1 | Hunter Biden | 537825 |
| 2 | Breonna Taylor | 406259 |
| 3 | taekook | 246030 |
| 4 | Catholic | 160597 |
| 5 | Wanton Endangerment | 139451 |
| 6 | Rand Paul | 104876 |
| 7 | #BiVisibilityDay | 85995 |
| 8 | Gale Sayers | 65424 |
| 9 | ashton | 64042 |
| 10 | #RussianRon | 62518 |
| 11 | #WednesdayWisdom | 47188 |
| 12 | Tyrod | 41580 |
| 13 | Daniel Cameron | 40977 |
| 14 | bagg | 26452 |
| 15 | #IWONHOYOU | 24174 |
| 16 | Cosgrove | 21863 |
| 17 | #RIPAnimal | 19179 |
| 18 | Black Widow | 18784 |
| 19 | #FALLIN4DANIEL | 13687 |
| 20 | #SUPERBLOOM | 12400 |
| 21 | Dr. Birx | 11879 |
| 22 | Chocolate-dipped | <10k |
| 23 | Matheson | <10k |
| 24 | Pickled | <10k |
| 25 | #LaterCon | <10k |
| 26 | #CashAppWYR | <10k |
| 27 | #NationalDunkinDaySweepstakes | <10k |
| 28 | #YIAYboys | <10k |