| Rank | Twitter Trend | Tweets Count |
|---|---|---|
| 1 | Amy Coney Barrett | 890197 |
| 2 | Catholic | 207747 |
| 3 | #UFC253 | 45101 |
| 4 | #MostRequestedLive | 33623 |
| 5 | #ConfirmACB | 28289 |
| 6 | #StupidityIn4Words | 19096 |
| 7 | Mississippi State | 13662 |
| 8 | Texas Tech | 11379 |
| 9 | Mike Leach | 10537 |
| 10 | #HookEm | <10k |
| 11 | Longhorns | <10k |
| 12 | Casimero | <10k |
| 13 | #AnswerUsPedoTube | <10k |
| 14 | #GeauxTigers | <10k |
| 15 | #AirRaid | <10k |
| 16 | Bo Pelini | <10k |
| 17 | #UGAvsARK | <10k |
| 18 | #GoDawgs | <10k |
| 19 | #FreeRTX3080 | <10k |
| 20 | Coach O | <10k |
| 21 | Dylan Moses | <10k |
| 22 | Big 12 | <10k |
| 23 | Marc Staal | <10k |
| 24 | #HailState | <10k |
| 25 | kylin hill | <10k |
| 26 | #FSUvsMIA | <10k |
| 27 | Mathis | <10k |
| 28 | Myles Brennan | <10k |
| 29 | Waddle | <10k |
| 30 | #WreckEm | <10k |
| 31 | #MSSTvsLSU | <10k |
| 32 | Tom Herman | <10k |